Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure

Table 1 Genetic susceptibility and lung cancer in nerver smokers

Author/year	Region	No. of pts.	Histologic type	Genetic markers
McKay JD et al. 2008 [20]	France	3259 case	adenocarcinoma	CLPTM1L-TERT
McKay JD et al. 2008 [20]	France	4159 control	adenocarcinoma	CLPTM1L-TERT
Hsiung CA et al. 2010 [21]	Taiwan	584 case	adenocarcinoma	CLPTM1L-TERT
Hsiung CA et al. 2010 [21]	Taiwan	585 control	adenocarcinoma	CLPTM1L-TERT
Iwamoto S et al. 2014 [22]	Japan	341	NSCLC	EPAS1
Kang HG et al. 2014 [23]	Korea	360	lung cancer	CSF1R, TP63, CIR1
Shen L et al. 2014 [24]	China	1003	adenocarcinoma	ATM
Yongjun Zhang MM et al. 2013 [25]	China	400	NSCLC	TGM5, PPAP2B, PSMA4
Sun Z et al. 2014 [26]	USA	27	adenocarcinoma	EGFR, TP53, KRAS, RPS6KB2, ATXN2, DHX9, PTPN13, SP1, SPTAN1, MYOF
Bennett WP et al. 1999 [27]	USA	106	lung cancer	GSTM1
Ahn MJ et al. 2012 [28]	Korea	446	NSCLC	APCDD1, NAPG, FAM38B
Lim WY et al. 2011 [29]	Singapore	433		IL6, cyclooxygenase-2, PPAR-γ, IL1RN
Li Y et al. 2010 [30]	USA	1489	lung cancer	13q31.3 GPC5
Wu X et al. 2013 [31]	USA	1583	NSCLC	LEMD3, TMBIM, ATXN7L2, SHE, ITIH2, NUDT5
Zhou W et al. 2003 [32]	USA	1091	lung cancer	XRCC1, ERCC2
Hung RJ et al. 2003 [33]	France	302 case	lung cancer	CYP1A1, GSTM1
Hung RJ et al. 2003 [33]	France	1631 control	lung cancer	CYP1A1, GSTM1
Liu L et al. 2014 [34]	China	298 case	lung cancer	GPC5
Liu L et al. 2014 [34]	China	599 control	lung cancer	GPC5

ISSN: 2052-4374